Polycyanodithiino aromatic n-heterocyclic compounds

ABSTRACT

Novel polycyanodithiino aromatic N-heterocyclic compounds are prepared. These are useful as fungicides and bactericides.

United States Patent [191 Kurihara et al.

[ 51 Sept. 25, 1973 POLYCYANODITHIINO AROMATIC N-HETEROCYCLIC COMPOUNDS Inventors: Norman H. Kurihara, Walnut Creek; Donald E. Bublitz, Concord, both of Calif.

The Dow Chemical Company, Midland, Mich.

Filed: Jan. 7, 1971 Appl. No: 104,799

Assignee:

U.S. Cl. 260/25() R, 424/250, 7l/90, 260/250 A Int. Cl. C07d 51/76, C07d 51/78 Field of Search 260/250 R Primary Examiner-Nicholas S. Rizzo Att0rneyGriswold & Burdick, S. Preston Jones and C. Kenneth Bjork [57] ABSTRACT Novel polycyanodithiino aromatic N-heterocyclic compounds are prepared. These are useful as fungicides and bactericides.

4 Claims, N0 Drawings POLYCYANODITHIINO AROMATIC N-HETEROCYCLIC COMPOUNDS aro- 5 matic N-heterocyclic compounds corresponding to the formula In this and succeeding formulae, R represents 2,3-pyrazinediyl 5 ,6-dichloro'2,3-pyrazinediyl 3,6-dichloro-4,5-pyridazinediyl 6-chloro-3,4-pyridazinediyl 5,6,7,8-tetrachloro-2,3-quinoxalinediyl 2,3-dicyano-[p-dithiino(2,3-b )pyrazine-6,7-diyl] 2,3,8-tricyano-[p-dithiino(2,3-b)pyridine-6,7-diyl] 5 ,6-dicyano-l p-dithiino(2,3-e)-2,l ,3-benzothiadiazole- 8,9-diyl] 6,7-dibromo-2,l,3-benzothiadiazole-4,S-diyl 2,1 ,3-benzothiadiazole-5,6-diyl N f s N For convenience, the compounds of the present invention are identified asdithiino compounds. The dithiino compounds of the present invention are crystalline solids which are of very low solubility in water and only slightly soluble in common organic solvents such as acetone and benzene.

The new compounds of the present invention are prepared by reacting disodium-cis-l,2-dicyano-l,2- ethylene dithiolate with an appropriate haloaromatic compound. The reaction can be characterized as follows:

s R solvent CN R 2 NaX A CN wherein R is as hereinbefore defined and X is chloro or bromo.

In carrying out the reaction, the haloaromatic compound starting material is dissolved in a solvent such as, for example, dimethylformamide, acetone, N-methylpyrrolidone or dimethylacetamide. To this mixture is thereafter added the disodium-cis-1,2-dicyano-l,2- ethylene dithiolate. The reactants are maintained under agitation during the reaction period. The reaction is carried out at temperatures between about 25 and about 100 C. and depending upon the specific reactants and solvent employed, the reaction is usually complete in from about 8 hours to about hours. Upon completion of the reaction, the reaction mixture is poured into cold water or poured over ice and the crude solid product which precipitates is recovered by filtration or other conventional separator-y procedures. The product can then be purified by conventional techniques such as, for example, elution on a silica gel column with a solvent such as chloroform, extraction with a solvent such as chloroform followed by crystallization from a mixture of ethyl acetate and acetone or other well known purification procedures.

DESCRIPTION OF SOME PREFERRED EMBODIMENTS The following examples illustrate the present invention and the manner by which it can be practiced but, as such, should not be construed as limitations upon the overall scope of the same.

Example I p-Dithiino(2,3-b) pyrazine-2,3-dicarbonitrile A solution is prepared containing 3.7 grams of disodium-cis-l ,2-dicyano-l ,Z-ethylene dithiolate dissolved in 35 milliliters of dry dimethylformamide and maintained under agitation. To this agitated solution is added a solution containing -3.0 grams of 2,3-dichloropyrazine in 35 milliliters of dry dimethylformamide. The mixture was maintained overnight (about 14 hours) under agitation at 50 C. and thereafter poured into ice water. The crude solid p-dithiino(2,3b)pyrazine-2,3- dicarbonitrile product which precipitated was recovered by filtration and dried. The solid product was thereafter eluted with chloroform on a silica gel column. The product was recovered in a yield of 23 percent of theoretical and melted at l63-l65 C. Upon analysis, the product was found to have carbon, hydrogen and nitrogen contents of 43.9, 0.8 and 25.8 percent, respectively, as compared with the theoretical contents of 44.0, 0.9 and 25.6 percent, respectively, calculated for the above-named structure.

Example ll 6,7-Dichloro-p-dithiino(2,3-b)pyrazine-2,3-

dicarbonitrile N s ci O ION Cl N S CN To an agitated solution of l 1.7 grams of tetrachloropyrazine dissolved in 50 milliliters of dry dimethylformamide was added a solution of 10.0 grams of disodium-cis-l,2-dicyano-l,2-ethylene dithiolate dissolved in 100 milliliters of dry dimethylformamide. The temperature of the mixture rose to 55 C. and then dropped to room temperature. The mixture was maintained under agitation in a closed vessel for 3 days (about 72 hours). The reaction mixture was thereafter poured into 1 liter of cold water. The crude 6,7- dichloro-p-dithiino(2,3-b)fpyrazine-2,S-dicarbonitrile product which precipitated was recovered by suction filtration, dried and purified by elution with chloroform on a silica gel column. The product was recovered in a yield of 45 percent of theoretical and melted at 184 C. Upon analysis by mass spectrometry, the product was found to have a molecular weight of 286, based on chlorine having an atomic weight of 35.

Example lll 4,5-Dibromo-p-dithiino(2,3-

e)(2, l ,3 )benzothiadiazole-7,8-dicarbonitrile To a solution of IO grams of tetrabromobenzothiadiazole in 200 milliliters of dry dimethylformamide was added 4 grams of disodium-cis-l,2-dicyano-1,2- ethylene dithiolate. The mixture was maintained under agitation at room temperature for 48 hours and thereafter poured into 800 milliliters of cold water. The solid which precipitates is recovered by filtration, dried and chromatographed on a silica gel column with chloroform as the solvent. The purified solid was found to be a mixture of 0.55 gram of 4,5-dibromo-p-dithiino(2,3- e)(2,l,3 )benzothiadiazole which melted at 228 C. with decomposition and 0.65 gram of bis-pdithiino(2,3-e:2',3'-g)(2,l,3)benzothiadiazol-5,6,9,l0- tetracarbonitrile corresponding to the formula NN l/ I it...

melting at 276279 C., with decomposition, prepared by the reaction of 2,3,5,6,7,8-hexachloroquinoxaline and disodium-cis-l,2-dicyano-l,2-ethylene dithiolate in dimethylformamide. Bis-p-dithiino(2,3-b:2',3-e)pyrazine-2,3,7,8-

tetracarbonitrile NCTSYN\/S\IFCN i i melting at 280 C., with decomposition, prepared by the reaction of tetrachloropyrazine with disodium-cisl,Z-dicyano-l,2-ethylenedithiolate in dimethylformamide.

p-Dithiino(2,3-f)(2,l ,3 )benzothiadiazole-6,7- dicarbonitrile having a molecular weight of 274 and prepared by the reaction of 5,6-dibromo-2,l ,3-benzothiadiazole and disodium-cis-l ,2-dicyano-l ,Z-ethylenedithiolate.

A mixture of 5,6-dichloro-p-dithiinopyridinc-2,3,8- tricarbonitrile, 7,8-dichloro-p-dithiinopyridine-2,3,6- tricarbonitrile and 5,8-dichloro-p-dithiinopyridine- 2,3,7-tricarbonitrile having a melting point of 230-233 C. prepared by the reaction of tetrachloro- Z-cyanopyridine and disodium-cis-l,2-dicyano-l,2- ethylenedithiolate in dimethylformamide. 6,7-Dichloro-p-dithiino(2,3-b)pyridine-2,3,8-tricarbonitrile having a melting point of l56l60 C. prepared by the reaction of tetrachloro-4-cyanopyridine and disodium-cis-l,2-dicyano-l,Z-ethylenedithiolate in dimethylformamide at 40 C. for 24 hours.

A mixture of 6,8-dichloro-p-dithiino(2,3-b)pyridine- 2,3,7-tricarbonitrile and 5,7-dichloro-p-dithiino(2,3- c)pyridine-2,3,8-tricarbonitrile melting at l60200 C. and prepared by the reaction of tetrachloro-3- cyanopyridine and disodium-cis-l,Z-dicyano-l,2- ethylenedithiolate in dimethylformamide. Bis-p-dithiino-(2,3-b:2',3'-e)pyridine-2,3,7,8,lO-penta-carbonitrile S S N01 \/\H/ IUN l /s A N melting at 298300 C. and prepared by the reaction of tetrachloro-4-cyanopyridine and disodium-l,2- dicyano-l,Z-ethylenedithiolate in dimethylformamide at room temperature for60 hours. 3-Chloro-p-dithiino-(2,3-c)pyridazine-6,7- dicarbonitrile melting at 145 C., with decomposition, and prepared by the reaction of 3,4,6-trichloropyridazine with disodium-cis-1,2-dicyano-l,Z-ethyIenedithiolate in dimethylformamide. 5,8-Dichloro-p-dithiino(2,3-d)pyridazine-2,3- dicarbonitrile ganisms. They can be applied to the aerial portions of many growing plants to control leaf-attacking fungal organisms or dispersed in soil or applied to plant seeds to control the root and seed attacking organisms of mold and damping off. In still other operations they can be applied to orchard floor surfaces to control overwintering spores of many fungal organisms. In still further operations, the compounds of the invention or compositions containing them as toxic constituents can be included in and on plaster, ink, wallboard, textiles, paper, adhesives, soaps, synthetic detergents, cutting oils, polymeric materials, embalming fluids, oil paints and latex paints to prevent the attack of various fungal organisms and the subsequent economic loss due to the degradation of such products by microorganisms. Also, the compounds can be distributed in textiles, cellulosic materials or in grain or can be employed in the impregnation of wood and lumber to preserve and protect such products from the attack of the organisms of rot, mold and decay.

The exact concentration of the toxicant to be employed in the treating compositions is not critical and may vary considerably provided the required dosage of the effective agent is supplied in the ink, adhesive, soap, cutting oil, polymeric material, paint, textile, paper, wood or growth medium or upon plant foliage. The concentration of toxicant in liquid compositions generally is from about 0.0001 to 50 percent by weight. Concentrat'ions up to 95 percent by weight are oftentimes conveniently employed, particularly in concentrate compositions. In dusts, the concentrations of the toxicant can be from about Oil to 95 percent by weight. In compositions to be employed as concentrates, the toxicants can be present in a concentration of from 5 to 98 percent by weight. For use as a foliar spray or in seed treatment, it is often convenient to apply the compounds as wettable powders.

In a representative operation, each of the compounds 3-chloro'p-d ithiino(2,3-c)pyridazine; 6,7-dichloro-pdithiino(2,3-b)pyrazine-Z,B-dicarbonitrile; bis-pdithiino(2,3-b:2,3'-e)pyridine-2,3,7,8,l0- pentacarbonitrile; 5,8-dichloro-p-dithiino(2,3- d)pyridazine-2,3-dicarbonitrile and 6,7-dichloro-pdithiino(2,3-b)-pyridine-2,3,8-tricarbonitrile, when employed as the sole toxicant in an aqueous composition at a concentration of 400 parts by weight per million parts of the ultimate composition, was found to give substantially complete kill and control of the causative organism of downey mildew.

In a further operation, each of (l) 4,5-dibromo-pdithiino(2,3-e)(2, l ,3 )benzothiadiazole-7,8- dicarbonitrile and (2) a mixture of 6,8-dichloro-pdithiino-(2,3-b)pyridine-2,3,7-tricarbonitrile and 5,7- dichloro-p-dithiino(2,3-c)pyridine+2,3,B-tricarbonitrile were also foundto give substantially complete kill and control of the causative organism of downey mildew when said mixture was employed, as the sole toxicant, in an aqueous composition at a concentration of 400 parts by weight per million parts of the ultimate composition.

In other representative operations, each of the compounds, 6,7-dichloro-p-dithiino(2,3-b)pyridine-2,3,8- tricarbonitrile; p-dithiino(2,3-b)pyrazine-2,3- dicarbonitrile; bis-p-dithiino(2,3-b:2',3'-e)pyridine- 2,3,7,8,IO-pentacarbonitrile; 6,7, 8,9-tetrachloro-pdithiino(2,3-b)-quinoxaline-2,3-dicarbonitrile; bis-pdithiino(2,3-b:2',3'-e)pyrazine-2,3,7,8- tetracarbonitrile; 'bis-p-dithiino-( 2,3-ez2 ,3

g)(2, l ,3 )benzothiadiazole-S ,6,9,IO-tetracarbonitrile; 5,8-dichloro-p-dithiino(2,3-d)pyridazine-2,3- dicarbonitrile; 6,7-p-dithiino(2,3-b)pyrazine-2,3- dicarbonitrile, when employed as the sole toxicant in an aqueous composition at a concentration of 400 parts by weight per million parts of the ultimate composition was found to give substantially complete kill and control of the causative organism of rice blast.

In a similar operation, each of (l) a mixture of 6,8- dichloro-p-dithiino(2,3-b)pyridine-2,3,7- tricarbonitrile and 5,7-dichloro-p-dithiino(2,3- c)pyridine-2,3,8-tricarbonitrile and (2) 4,5-dibromo-pdithiino(2,3-e)(2,l ,3 )-benzothiadiazole-7,8- dicarbonitrile were also found to give substantially complete kill and control of the causative organism of rice blast, when said mixture was employed as the sole toxicant in an aqueous composition at a concentration of 400 parts by weight per million parts of the ultimate composition.

In another operation, each of the compounds 3- chloro-p-dithiino(2,3-c)pyridazine-6,7-dicarbonitrile; 6,7-dichloro-p-dithiino(2,3-b)pyrazine-2,3- dicarbonitrile; 5,6-dichloro-p-dithiino(2,3- d)pyridazine-2,3-dicarbonitrile and 6,7-dichloro-pdithiino(2,3-b)pyridine-2,3,8-tricarbonitrile was found to give substantially complete kill and control of the causative organism of tomato late blight, when said compound was employed as the sole toxicant in an aqueous dispersion at a concentration of 400 parts by weight per million parts of the ultimate dispersion.

In an additional operation, each of the compounds p-dithiino(2,3-b)pyrazine-2,3-dicarbonitrile; 3-chlorop-dithiino(2,3-c)pyridazine-6,7-dicarbonitrile; 6,7- dichloro-p-dithiino(2,3-b)pyrazine-2,3-dicarbonitrile; bis-p-dithiino(2,3-b:2,3-e)pyrazine-2,3,7,8- tetracarbonitrile; 6,7-dichloro-p-dithiino(2,3- b)pyridine-Z,3,8-tricarbonitrile and bis-p-dithiino(2,3- c:2',3'-g)(2,l,3 )-benzothiadiazole-S,6,9,ltetracarbonitrile, when employed as the sole toxicant in a nutrient agar at a concentration of about 500 parts by weight of the compound per million parts of agar, is found to give 100 percent kill and control of the organisms Staphylococcus aureus, Trichophyton mentagrophytes, Candida albicans, Bacillus subtilis, Pullularia pullulans, Mycobacterium phlei, Aspergillus terreus, Candida pelliculosa, Rhizopus nigricans, Ceratocystis ips and Cephaloascus fragans.

PREPARATION OF STARTING MATERIALS 1 The disodium-cis-l ,2-dicyano-l,2-ethylenedithiolate employed as a starting material in the present invention is a well-known compound and can be prepared by the method taught in Muetterties Inorganic Synthesis" Volume X, page 1 I, wherein sodium cyanide is reacted with carbon disulfide and dimethylformamide followed by dimerization of the reaction product.

The chloro N-heterocyclic aromatic compounds em ployed as starting materials can be prepared by the method taught in U. S. Pat. No. 3,420,833 wherein the unchlorinated compound is subjected to vapor phase chlorination at temperatures of from about 400 C. to about 700 C. The chlorinated benzothiadiazole can be prepared by a similar procedure.

The tetrabromobenzothiadiazole employed as a starting material is a known compound and can be prepared by the melt phase bromination of benzothiadiazol.

The 5,6-dibromo-(2,l ,3)-benzothiadiazole employed as a starting material is a known compound and can be prepared by the method taught in J. Heterocyclic Chemistry 7, 629 (1970) wherein 4,5-dibromo-ophenylene diamine is reacted with thionylaniline under reflux conditions in the presence of toluene.

What is claimed is:

l. A polycyanodithiino aromatic N-heterocyclic compound corresponding to the formula 5 CN B l wherein R represents 2,3-pyrazinediyl 5 ,6-dichloro-2,3-pyrazinediyl S,6,7,8-tetrachloro-2,3-quinoxalinediyl 01 A N c1- CITKIAN/ (:1

2. The compound of claim 1 which is p-dithiino(2,3-

b)pyrazine-2,3-dicarbonitrile corresponding to the formula (NVSTCN ol 1 ON 4. The compound of claim 1 which is 6,7-dichloro-pdithiino(2,3-b)pyrazine-Z,3-dicarbonitrile corresponding to the formula 22w L W E -W @FMCFE QLR'HM L oL-W Patent 3.761.475 Dated SeptQmber'ZS, 1973 fl Normn H, Kurihara and Donald E. Bublitz It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown belom:

Column 8, line 20, delete n (EN u and subs*izitutev w v Signed and sealed this 12th day of March 1974.

(SEAL) Attest; EDWARD MLFLETCHER JR. c. MARSHALL DANN Commissioner of Patents Attescing Officer 

2. The compound of claim 1 which is p-dithiino(2,3-b)pyrazine-2, 3-dicarbonitrile corresponding to the formula
 3. The compound of claim 1 which is 6,7,8,9-tetrachloro-p-dithiino(2,3-b)quinoxaline-2,3-dicarbonitrile corresponding to the formula
 4. The compound of claim 1 which is 6,7-dichloro-p-dithiino(2,3-b)pyrazine-2,3-dicarbonitrile corresponding to the formula 